理学博士，现为山东大学微生物技术国家重点实验室教授，博士生导师。主持国家自然科学基金面上项目、国家重点研发计划国际合作等项目，入选中部组“青年千人”、山东省“青年泰山学者”，获得“国家自然基金委优秀青年基金”和“山东省杰出青年基金”资助。2007 年本科毕业于山东大学生命科学学院。2012 年博士毕业于清华大学，师从施一公教授，对肠道病原微生物抗酸性系统中的一个膜蛋白转运底物的分子机制进行研究，揭示了肠道病原微生物一类抗酸性系统的作用机制。为了深入研究肠道病原菌与宿主的相互作用及致病机理，2012-2017在耶鲁大学，与Jorge Galan 教授合作开展博士后研究工作，以沙门氏菌、致病性大肠杆菌等肠道病原菌为研究对象，围绕“病原微生物致病机制”这一重要科学问题开展研究。阐释了肠道病原微生物通过与宿主共进化来适应宿主以及人伤寒沙门氏菌引发伤寒的分子机制和生物学意义，为开发新型抗菌药物提供了思路和靶点，为优化人伤寒沙门氏菌的动物模型提供了新的突破口和理论基础。以通讯作者或第一作者/共第一作者身份发表研究论文24篇，包括 1 篇 Science(2009)，2 篇Nature (2010,2013)，1 篇Cell (2014)，1 篇 Cell Host & Microbe (2016)，2篇 Nature Microbiology (2017、2021) 和Toxins (2020)等。并受邀与Jorge Galan 教授合作撰写综述论文 1 篇。其中 2 篇被国际论文评估机构 Faculty of 1000 推荐为“必读”论文， 1 篇(Nature，2013) 被 Nature 同期配文推荐，1 篇(Nature Microbiology，2017) 被 Nature Microbiology 配文推荐。总引用超过1000次，H指数为10。 2011 年获吴瑞奖， 2014 年获耶鲁大学 James Hudson Brown - Alexander B. Coxef fellowship 奖，2015 年获美国 Blavatnik Regional Award Finalist 奖。

 2017年7月，加入山东大学微生物技术国家重点实验室，开展肠道菌与宿主之间相互作用的分子机制的研究，并以此为基础探索调整肠道稳态的新策略。

研究方向

1.   病原微生物致病的分子机制。

2.   肠道病原微生物（沙门氏菌）、肠道菌群（拟杆菌）以及宿主之间相互作用的分子机制。

代表论文

   2017年至今

（1）Dongdong Wang #， Zhe Chen #， Chunyu Xu，Xuyao Jiao，Min Yue， Xiang Gao*. (2025) Functional synergy of heteropentameric B subunits underlies virulence in a Salmonella A2B5 toxin. PLoS Pathog. 21(11):e1013684.(#, Co-first author)

（2）Piqian Gong, Guobang Li, Weixun Li, Mengyuan Xu, Xuyao Jiao, Xudong Chen, Beile Gao, Xiang Gao*. (2025) Cryo-EM structure of the QseG-QseE complex reveals an accessory protein-driven two-component system activation mechanism. mBio. Published online Nov 17,2025.

（3）Weixun Li , Shuaining Zheng , Xiaoning Xu , Jing He , Xuyao Jiao , Mingyu Wang , Wei Hu , Shengying Li , Xianzhi Jiang , Bentley Lim , Feng Shao , Xiang Gao*. (2025) A conserved adaptor orchestrates co-secretion of synergistic type VI effectors in gut Bacteroidota. Cell Host & Microbe. 33(11):1901-1915.

（4）Jing He, Zhe Chen, Kun Jiang, Yan Yang, Weixun Li , Xiaotong Wang, Xiaoning Xua, Shuaining Zheng, Xuyao Jiao, Xudong Chen , Liujie Huo, Bentley Lim, Shuang-Jiang Liu, and Xiang Gao* .(2025) A nonenzymatic effector disrupts Bacteroides cell wall homeostasis via OmpA targeting to mediate interbacterial competition. PNAS.122(41):e2513207122.

（5）Weixun Li， Xiang Gao*.(2025) Structural plasticity of bacterial ubiquitin-like proteins in stress sensing. STRUCTURES.33(6):989-991.

（6）Yuanyuan Jiang#, Piqian Gong#, Zijia Li#, Zhong Li, Yuxuan Li, Binju Wang, He Huang*, Wei Peng*, Xiang Gao*, and Shengying Li* (2025) Unexpected Activities of CYP152 Peroxygenases towards Non-carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility. Angewandte Chemie International Edition. 64(31): e202506614.(#, Co-first author)

（7）Kun Jiang#, Xinxin Pang#, Weixun Li#, Xiaoning Xu, Yan Yang, Chengbin Shang & Xiang Gao*.（2025） Interbacterial warfare in the human gut: insights from Bacteroidales’ perspective.Gut Microbes. 17(1)：2473522.(#, Co-first author)

（8）Xiao Ding , Nick Lung-Ngai Ting , Chi Chun Wong , Pingmei Huang , Lanping Jiang , Chuanfa Liu , Yufeng Lin , Shiyu Li , Yujie Liu , Mingxu Xie , Weixin Liu , Kai Yuan , Luyao Wang , Xinyue Zhang , Yanqiang Ding , Qing Li , Yang Sun , Yinglei Miao , Lanqing Ma , Xiang Gao , Weixun Li, William K K Wu , Joseph J Y Sung , Sunny Hei Wong , Jun Yu*. (2025) Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity. Cell Host &Microbe. 33(6):941-956.

（9）Yuqing Yan , Li Tian , Ying Zhao , Baoqin Xuan , Xitao Xu , Jinmei Ding , Weixun Li , Yi-Lu Zhou , Yue Zhang , Yanru Ma , Lijun Ning , Zhenyu Wang , Yi Jiang , Xiaoqiang Zhu , Xiaowen Huang , Muni Hu , Nan Shen , Xiang Gao , Jing-Yuan Fang , Zhe Cui *, Zhijun Cao* , Haoyan Chen* , Xiaoyan Wang* , Jie Hong*. (2025) Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease. J Crohns Colitis. 19(3):jjae179.

（10）Bentley Lim, Jinghua Xu, Igor H. Wierzbicki, Carlos G. Gonzalez, Zhe Chen, David J. Gonzalez, Xiang Gao, and Andrew L. Goodman*. (2025) A human gut bacterium antagonizes neighboringbacteria by altering their protein-folding ability.Cell Host &Microbe. 33(2):200-217.

（11）Ming Tong^#,Jinghua Xu^#,Weixun Li^#,Kun Jiang^#,Yan Yang,Zhe Chen, Xuyao Jiao,Xiangfeng Meng,Mingyu Wang,Jie Hong,Hongan Long,Shuangjiang Liu,Bentley Lim, andXiang Gao*(2024) A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues. Nat Commun. 15:8794. (^#, Co-first author).

（12）Kun Jiang*, Xiang Gao*(2024) Current advances on Vip3 highlight the promising potential of bacterial insecticidal proteins,Trends in Microbiology. 32(8):732-735.

（13）Kun Jiang^#, Weixun Li^#, Ming Tong^#, Jinghua Xu^#, Zhe Chen^#, Yan Yang, Yuanrong Zang, Xuyao Jiao, Chang Liu, Bentley Lim, Xianzhi Jiang, Jiawei Wang, Dalei Wu, Mingyu Wang, Shuang-Jiang Liu, Feng Shao, and Xiang Gao*(2023) Human Gut Symbionts Secrete a Ubiquitin Homologue that Inactivates an Essential Periplasmic Chaperone for Interbacterial Competition. Nature Microbiology. 9(1):70-84. (^#, Co-first author).

（14）KunJiang^#,ZheChen^#, Yuanrong Zang, Yiting Shi, Chengbin Shang, XuyaoJiao, Jun Cai, Xiang Gao*（2023）Functional Characterization of Vip3Aa from Bacillus Thuringiensis Reveals the Contributions of Specific Domains to Its Insecticidal Activity. J Biol Chem. 299(3):103000. （^#, Co-first author）.

（15）Yunjun Pan^#, Guobang Li^#, Ruxin Liu, Jiawei Guo, Yunjie Liu, Mingyu Liu, Xingwang Zhang, Luping Chi, Kangwei Xu, Ruibo Wu, Yuzhong Zhang, Yuezhong Li, Xiang Gao*, Shengying Li*(2023) Unnatural Activities and Mechanistic Insights of Cytochrome P450 PikC Gained from Site-specific Mutagenesis by Non-canonical Amino Acids.Nat Commun, 14(1):1669.（^#, Co-first author）.

（16）Zhe Chen, Yiting Shi, Dongdong Wang, Xiaoyu Liu, Xuyao Jiao,Xiang Gao*, Kun Jiang*(2023)Structural insight into Bacillus thuringiensis Sip1Ab reveals its similarity to ETX_MTX2 family beta-pore-forming toxin. Pest Manag Sci. 79(11):4264-4273.

（17）KunJiang^#, ZheChen^#, YitingShi, YuanrongZang, ChengbinShang, XiHuang, JiaheZang, ZhudongBai, XuyaoJiao, JunCai, XiangGao*. (2023) A Strategy to Enhance the Insecticidal Potency of Vip3Aa by Introducing Additional Cleavage Sites to Increase Its Proteolytic Activation Efficiency. Engineering Microbiology, 3(4):100083.(^#, Co-first author).

（18）Xiaoyu Liu, Zhe Chen, Xuyao Jiao, Xukai Jiang, Jicheng Qiu, Fuping You, Hongan Long, Hongzhi Cao, Casey C. Fowler, Xiang Gao* (2022) Molecular Insights into the Assembly and Functional Diversification of Typhoid. Toxin.mBio. 13(1): e0191621.

（19）Lili Cao,Yujie Luo, Xuefei Guo,Shengde Liu, Siji Li, Junhong Li, Zeming Zhang, Yingchi Zhao, Qiao Zhang, Feng Gao, Xiong Ji, Xiang Gao, Yunfei Li*andFuping You*（2022）SAFA Facilitates Chromatin Opening of Immune Genes through Interacting with Nascent Antiviral RNAs. Plos Pathogens. 18(6):e1010599.

（20）Jiao Pan,Weiyi Li,Jiahao Ni,Kun Wu, Iain Konigsberg, Caitlyn E. Rivera, Clayton Tincher,Colin Gregory, Xia Zhou, Thomas G. Doak, Heewook Lee, Yan Wang, Xiang Gao,Michael Lynch and Hongan Long*(2022).Rates of Mutations and Transcript Errors in the Foodborne Pathogen Salmonella enterica subsp. enterica. Molecular Biology and Evolution. 39(4):msac081.

（21）Adaobi Ojiakor, Rachel N Gibbs, Zhe Chen, Xiang Gao, Casey C Fowler* (2022). The Evolutionary Diversification of theSalmonella artABToxin Locus. Front Microbiol. 13:1016438.

（22）Jinghua Xu, Jiuqing Wang, Aijun Liu, Yanqing Zhang, Xiang Gao* (2021)Structural and Functional Analysis of SsaV Cytoplasmic Domainand Variable Linker States in the Context of the InvA-SsaV Chimeric Protein. Microbiology Spectrum. 9(3):e01251-21.

（23）Huan Lian^#, Kun Jiang^#, Ming Tong^#, Zhe Chen, Xiaoyu Liu, Jorge E. Galan*, and Xiang Gao* (2021)The Salmonella Effector Protein SopD targets Rab8 GTPase to positively and negative regulate the inflammatory response. Nature Microbiology. 6(3)658-671.(^#, Co-first author).

（24）Kun Jiang^#, Yan Zhang^#, Zhe Chen^#, Dalei Wu, Jun Cai and Xiang Gao* (2020) Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin of Bacillus thuringiensis. Toxins. 12: 1-15. (^#, Co-first author).

（25）Peiyan Wang^#, Siji Li^#, Yingchi Zhao, Baohuan Zhang, Yunfei Li, Shengde Liu, Hongqiang Du, Lili Cao, Meiling Ou, Xiaohong Ye, Peng Li, Xiang Gao, Penghua Wang, Chunxia Jing, Feng Shao, Guang Yang* and Fuping You* (2019) The GRA15 Protein fromToxoplasma gondiiEnhances Host Defense Responses by Activating the Interferon Stimulator STING. J. Biol. Chem. 294(45): 16494-16508.(^#, Co-first author).

（26）Lili Cao^#, Shengde Liu^#, Yunfei Li, Guang Yang, Yujie Luo, Siji Li, Hongqiang Du, Yingchi Zhao, Dandan Wang, Jingxuan Chen, Zeming Zhang, Mo Li, Songying Ouyang, Xiang Gao, Yujie Sun, Zekun Wang, Long Yang, Rongtuan Lin, Penghua Wang and Fuping You* (2019) The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.Cell Host Microbe. 26(3): 369-384.(^#, Co-first author).

（27）Yiqiao Bao, Andrew A. Verdegaal, Brent W. Anderson, Natasha A. Barry, Jing He,Xiang Gao, Andrew L. Goodman (2021) A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria. mBio. 12(4): e00656-21.

（28）Xiang Gao,Lingquan Deng,Gabrielle Stack,Hai Yu,Xi Chen,Yuko Naito-Matsui,Ajit Varkiand Jorge E. Galan* (2017) Evolution of Host Adaptation in the SalmonellaTyphoid Toxin. Nature Microbiology. 12, 1592-1599.

（29）Casey Fowler, Shu-Jung Chang,Xiang Gao, Tobias Geiger, Gabrielle Stack and Galan, Jorge E*（2017）Emerging Insights into the Biology of Typhoid Toxin. Curr Opin Microbiol. 35: 70-77. (invited review paper).

   2017年以前

（1）Stefania Spanò^#, Xiang Gao^#, Sebastian Hannemann^#, María Lara-Tejero and Jorge E. Galan* (2016) A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP. Cell Host Microbe 19(2):216-26. (^#, Co-first author)

（2）Lingquan Deng^#, Jeongmin Song^#, Xiang Gao^#, Jiawei Wang, Hai Yu, Xi Chen, Nissi Varki, Yuko Naito-Matsui, Jorge Galan* and Ajit Varki* (2014) Host Adaptation of a Bacterial Toxin from the Human Pathogen Salmonella Typhi. Cell 159(6):1290-9. (^#, Co-first author)

（3）Jeongmin Song^#, Xiang Gao^# and Jorge E. Galan* (2013) Structure and Function of the Salmonella Typhi Chimaeric A(2)B(5) Typhoid Toxin. Nature 499(7458):350-4. (^#, Co-first author; Highlighted by F1000)

（4）Xiang Gao^#, Lijun Zhou^#, Xuyao Jiao, Feiran Lu, Chuangye Yan, Xin Zeng, Jiawei Wang and Yigong Shi* (2010) Mechanism of Substrate Recognition and Transport by an Amino Acid Antiporter. Nature 463, 828-832. (^#, Co-first author)

（5）Xiang Gao^#, Feiran Lu^#, Lijun Zhou^#, Shangyu Dang, Linfeng Sun, Xiaochun Li, Jiawei Wang and Yigong Shi* (2009) Structure and Mechanism of an Amino Acid Antiporter. Science 324, 1565-1568. (^#, Co-first author)

科研项目

1. 底盘细胞及微生物群落的设计与构建-基于生物群落自组织的活体材料设计与构建，国家重点研发计划，2024-2029，主持

2. 细菌六型分泌系统介导菌间拮爆抗的新机制，省自然重大基础类项目，2024-2027，主持

3. 双亚利桑那沙门氏菌类伤寒毒素组装模式及致病机制研究，国自然面上项目，2024-2027，主持

4. SK10-ARG-2，横向项目，2023-2024，主持

5. 肠道噬菌体在腹主动脉瘤中的病因学作用和应用转化价值的多模态研究，省自然重大基础类项目，2024-2026，参加 

6. 功能微生物（群）及其代谢产物调控动物发育和抗病分子机制子课题，国家重点研发计划，2023-2027，主持

7. 肠道菌群互作，国家自然科学基金优秀青年科学基金项目，2022-2024，主持

8. 致病微生物Ⅲ型分泌系统结构与功能的研究，国家重点研发计划，政府间国际科技创新合作重点专项，2019-2022，主持

9. 沙门氏菌SopD效应蛋白家族功能的研究以及人伤寒沙门氏菌动物模型的优化，国家自然科学基金委面上项目，2018-2021，主持

10. 国家海外高层次人才青年项目，2017-2020，主持

11. 新型冠状病毒现场快速联合检测技术及装备开发，山东省重点研发计划， 2020-2023，参加

12. 奶牛乳腺炎病学研究及新型疫苗研制，山东省自然科学基金重大基础研究项目，2019-2024，参加

13. 山东省泰山学者（青年项目），2017-2021，主持

14. 人体肠道微生物与人类健康，山东大学青年交叉科学创新群体，2020-2023，主持

15. 病原微生物的致病机制及抗感染药物的开发，山东大学国际科研合作种子基金，2019-2022，主持

学术奖励

      2015 年获 Blavatnik Regional Award Finalist

      2014 年获 James Hudson Brown - Alexander B. Coxe Fellowship

      2011 年获吴瑞奖

学术兼职

             中国遗传学会微生物遗传专业委员会委员                   2019-2028

              中国病理生理学会系统生物学医学专委会委员            2019-2028

              中国生物物理学会肠道菌群分会委员                          2021-2025

              《微生物学通报》编辑委员会编委                              2021-2026

              山东微生物学会基础微生物专业委员会副主任委员    2021-2026

              Engineering Microbiology杂志执行编委

              山东微生物学会第十届理事会理事                              2025-2030

        山东微生物学会青年专业委员会委员                          2025-2030

电话：+86-532-58631535

邮箱：xgao@sdu.edu.cn

办公室：山东大学青岛校区第周苑A座-319室